ABSTRACT
The coronavirus disease (COVID-19) is upsetting human well-being and the economy around the globe. Scientists have been trying some antiviral drugs to control the disease and transmission of the 2019-nCoV in vitro. Two of these compounds are Favipiravir (T-705) and Ribavirin. Topological index also known as connectivity index, is a molecular descriptor which is calculated based on the molecular graph of a chemical compound. Topological indices are used to predict different biological and physicochemical properties of chemical compounds. In this article, various significant topological degree-based indices and the M-polynomials are investigated for the Favipiravir(T-705) and Ribavirin. The results obtained may aid in the designing of new medicine for the treatment and prevention of COVID-19 and other diseases.